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Home Resources Presentations In pursuit of the leukemic stem cell: leveraging single-cell genomics and proteomics…

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Scientific presentation

In pursuit of the leukemic stem cell: leveraging single-cell genomics and proteomics to identify drivers of AML

Katherine D Cummins, MD FRACP FRCPA

Description

Dr. Cathy Smith from UCSF provides a case study on single-cell sequencing of polyclonal resistance to FLT3 inhibitors in acute myeloid leukemia (AML). She presents data taken over a period of 28, 48, and 92 days to reveal that NRAS clones were detectable in 0.1% of cells with single-cell analysis at 28 days, which was previously undetectable with bulk sequencing until relapse.

Scientific presentation

Interrogating Clonal Evolution in Acute Leukemias through Single-Cell Multi-omic (DNA+Fusion and DNA+Immunophenotype) Analysis

Morgan Drucker, MD

Scientific presentation

Epitope Editing in Hematopoietic Cells Enables Protection From CD45-directed Immunotherapies For The Treatment Of Blood Cancers And HIV Reservoir Elimination

Dr. Nils Wellhausen

Scientific presentation

Leverage Single-cell Multi-parametric Datasets to Advance Heme Oncology Pipelines

Azad Gucwa, PhD

14th World Clinical Biomarkers & Companion Diagnostics Summit (2024)

Scientific presentation

DKFZ Seminar: Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

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