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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
Scientific presentation

Investigation of AML clonal architecture with mutational and immunophenotypic profiling simultaneously from the same cell(s)

Linde Miles, PhD

Acute myeloid leukemia (AML) is a molecularly diverse hematology disease with a poor survival rate. Only 25% of patients diagnosed survive. Therefore, it is important to gain a better understanding of the disease progression by using new technologies like single-cell DNA sequencing. Leukemogenesis is thought to be a stepwise process. However, bulk sequencing only infers the order of mutation acquisition. Linde Miles, of Ross Levine’s lab at Memorial Sloan Kettering Cancer Center, shares findings from her study where she immunophenotyped and genotyped AML samples to track the order of mutations using a custom molecular panel, covering key genes for AML, MPN, and MDS. Furthermore, through a simple add-on to the workflow, she confirmed protein expression with molecular data to understand enrichment and differentiation patterns. Discover how the Tapestri Platform provides a true multi-omics approach for deeper insight into systems biology and patterns of tumor evolution, therapy response, and resistance.


Scientific presentation
CHIP’ing away at somatic mosaicism — Diving into the promises and challenges of characterizing clonal hematopoiesis of indeterminate potential
Ross Levine, MD
Kelly Bolton, MD, PhD
Jyoti Nangalia, MD, PhD
Todd Druley, MD, PhD
Scientific presentation
Meet the Authors: Clonal Heterogeneity in Acute Lymphoblastic Leukemia at Diagnosis and During Chemo Treatment
Jan Cools, PhD, VIB Center for Cancer Biology
Scientific presentation
AMP 2021 Corporate Workshop: Single-cell DNA and multi-omics strategies for untangling therapy-resistant mechanisms in oncology
John Lee, M.D., Ph.D., Fred Hutchinson Cancer Research Center & Julia Gouffon, Ph.D., Mission Bio
Association for Molecular Pathology 2021 Digital Experience (2021)
Scientific presentation
Do More Single Cell with Less – Tapestri Platform Expansion for Hematologic Malignancy Research
Koichi Takahashi, MD, PhD, MD Anderson Cancer Center & Jim Flynn, PhD, Mission Bio