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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
Scientific presentation

Single-cell DNA-Seq publication roundup: conducting large-scale studies to understand therapy resistance, remission, and relapse

Kelly Kaihara, PhD

Dr. Kelly Kaihara, from Mission Bio, reviews a series of publications from pharma and academic researchers that follow up on large-scale clinical trials and use single-cell DNA sequencing to better understand therapy resistance, remission, and relapse.

Publications reviewed include:
Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML. Choe et al. Blood Advances 2020
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML. DiNardo, C.D. et al. Blood 2020
Single-cell mutational profiling enhances the clinical evaluation of AML MRD. Ediriwickrema, A. et al. Blood Advances 2020
V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. Gao, Y. et al. Cancer Discovery 2019


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CHIP’ing away at somatic mosaicism — Diving into the promises and challenges of characterizing clonal hematopoiesis of indeterminate potential
Ross Levine, MD
Kelly Bolton, MD, PhD
Jyoti Nangalia, MD, PhD
Todd Druley, MD, PhD
Scientific presentation
Meet the Authors: Clonal Heterogeneity in Acute Lymphoblastic Leukemia at Diagnosis and During Chemo Treatment
Jan Cools, PhD, VIB Center for Cancer Biology
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AMP 2021 Corporate Workshop: Single-cell DNA and multi-omics strategies for untangling therapy-resistant mechanisms in oncology
John Lee, M.D., Ph.D., Fred Hutchinson Cancer Research Center & Julia Gouffon, Ph.D., Mission Bio
Association for Molecular Pathology 2021 Digital Experience (2021)
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Do More Single Cell with Less – Tapestri Platform Expansion for Hematologic Malignancy Research
Koichi Takahashi, MD, PhD, MD Anderson Cancer Center & Jim Flynn, PhD, Mission Bio