Single-cell sequencing methods have enabled multi-modal characterization of tumor heterogeneity to yield novel insights into tumor evolution, therapeutic response, and resistance in hematological disorders. Dr. Kelly Kaihara, from Mission Bio, reviews recent publications from MD Anderson Cancer Center, UCSF, Memorial Sloan Kettering, and Stanford Medicine that use the Mission Bio Tapestri Platform for single-cell analysis. See how researchers are using this groundbreaking technology to study single-cell multi-omics of DNA and Protein for the first time in a high-throughput fashion.