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Scientific presentation

Profiling clonal hematopoiesis in cancer survivors with single-cell DNA sequencing

Chuck Gawad, MD, PhD

Description

St. Jude’s has been treating pediatric cancer for approximately 60 years. Studies have shown that alkylating agents cause mispairings and further mutagenesis, which is associated with cardiac dysfunction and other chronic health conditions. Dr. Gawad’s lab has been working on using single-cell DNA sequencing, which can provide a high-resolution view of the clonal diversity present in our hematopoietic cells as we age, in addition to the occurrence of co-mutations. The hope is to obtain new insight into chronic medical conditions of childhood cancer survivors.

Scientific presentation

Interrogating Clonal Evolution in Acute Leukemias through Single-Cell Multi-omic (DNA+Fusion and DNA+Immunophenotype) Analysis

Morgan Drucker, MD

Scientific presentation

Epitope Editing in Hematopoietic Cells Enables Protection From CD45-directed Immunotherapies For The Treatment Of Blood Cancers And HIV Reservoir Elimination

Dr. Nils Wellhausen

Scientific presentation

Leverage Single-cell Multi-parametric Datasets to Advance Heme Oncology Pipelines

Azad Gucwa, PhD

14th World Clinical Biomarkers & Companion Diagnostics Summit (2024)

Scientific presentation

DKFZ Seminar: Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

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