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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
Scientific presentation

Profiling clonal hematopoiesis in cancer survivors with single-cell DNA sequencing

Chuck Gawad, MD, PhD

St. Jude’s has been treating pediatric cancer for approximately 60 years. Studies have shown that alkylating agents cause mispairings and further mutagenesis, which is associated with cardiac dysfunction and other chronic health conditions. Dr. Gawad’s lab has been working on using single-cell DNA sequencing, which can provide a high-resolution view of the clonal diversity present in our hematopoietic cells as we age, in addition to the occurrence of co-mutations. The hope is to obtain new insight into chronic medical conditions of childhood cancer survivors.


Scientific presentation
CHIP’ing away at somatic mosaicism — Diving into the promises and challenges of characterizing clonal hematopoiesis of indeterminate potential
Ross Levine, MD
Kelly Bolton, MD, PhD
Jyoti Nangalia, MD, PhD
Todd Druley, MD, PhD
Scientific presentation
Meet the Authors: Clonal Heterogeneity in Acute Lymphoblastic Leukemia at Diagnosis and During Chemo Treatment
Jan Cools, PhD, VIB Center for Cancer Biology
Scientific presentation
AMP 2021 Corporate Workshop: Single-cell DNA and multi-omics strategies for untangling therapy-resistant mechanisms in oncology
John Lee, M.D., Ph.D., Fred Hutchinson Cancer Research Center & Julia Gouffon, Ph.D., Mission Bio
Association for Molecular Pathology 2021 Digital Experience (2021)
Scientific presentation
Do More Single Cell with Less – Tapestri Platform Expansion for Hematologic Malignancy Research
Koichi Takahashi, MD, PhD, MD Anderson Cancer Center & Jim Flynn, PhD, Mission Bio