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technical note

Copy number variants (CNV) and single nucleotide variants (SNV) simultaneously detected in single cells

Cancer begins in a single cell within the DNA. These genetic mutations are often caused by single nucleotide variants (SNVs) and gene copy number variants (CNVs), including loss of heterozygosity (LOH). Differences in SNVs and CNVs contribute to cancer heterogeneity, making some clonal populations more virulent and drug-resistant than others. Accurately defining clonal populations and reconstructing clonal phylogenies can only be achieved through single-cell analysis and is critical for informed clinical research. Learn how to obtain both CNVs and SNVs from the Tapestri Platform using Tapestri Single-cell DNA Panels.



technical note
The State of Cell and Gene Therapy Characterization Survey Report
technical note
scTAM-seq: Leveraging Tapestri for profiling DNA methylation in single-cells
technical note
Identifying copy number variations (CNV) in single cells for breast cancer research (Language: Mandarin)
technical note
Identifying copy number variations (CNV) in single cells for breast cancer research
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