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technical note

Copy number variants (CNV) and single nucleotide variants (SNV) simultaneously detected in single cells

Cancer begins in a single cell within the DNA. These genetic mutations are often caused by single nucleotide variants (SNVs) and gene copy number variants (CNVs), including loss of heterozygosity (LOH). Differences in SNVs and CNVs contribute to cancer heterogeneity, making some clonal populations more virulent and drug-resistant than others. Accurately defining clonal populations and reconstructing clonal phylogenies can only be achieved through single-cell analysis and is critical for informed clinical research. Learn how to obtain both CNVs and SNVs from the Tapestri Platform using Tapestri Single-cell DNA Panels.


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AML subpopulations defined by SNV, CNV, and protein expression
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Single-cell DNA sequencing resolves the genetic complexity underlying CLL progression
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