One Cell. SNVs + Indels.

Because bulk misses the diversity that matters.

The average read-out from conventional bulk sequencing misses the rare events and underlying genetic diversity within and across cell populations. The Tapestri Platform is the first and only single-cell platform to simultaneously detect Copy Number Variants (CNVs) and Single Nucelotide Variants (SNVs) from the same cells. To resolve heterogeneity and improve patient stratification, therapy selection, and disease monitoring we need to detect rare clonal populations and identify co-occurrence and zygosity within every single cell.

  • Detect rare subclones down to 0.1%
  • Resolve clonal architecture
  • Identify mutation co-occurrence
  • “Single-cell DNA analysis allows us to actually observe the clonal composition of cancer, instead of guessing at it. This opens up the possibility of being able to make dynamic changes in treatment.”

    – Catherine Smith, MD

Why Do Single-Cell?

  • Detect variants
  • Simple and intuitive
  • Multiplex
  • Custom

The Tapestri Workflow

Sample prep

Simple protocol for cell staining

Library prep

Single workflow combines DNA and protein antibody panels

Sequencing

Single sequencing run for SNVs, CNVs, and proteins

Pipeline

Integrated pipeline for multi-omic analysis

Analysis

Powerful analysis and visualization software

Single-Cell Sequencing Reveals Clonal Heterogeneity in Acute Lymphoblastic Leukemia.

This webinar will outline a project that performs large-scale and integrative single-cell genome and transcriptome profiling of pediatric acute lymphoblastic leukemia (ALL) cases at diagnosis, during drug treatment, and in case of relapse.

Jan Cools, PhD
Professor Genetics KU Leuven, Group Leader VIB

  • Detect rare subclones down to 0.1%
  • Resolve clonal architecture
  • Identify mutation co-occurrence