The average read-out from conventional bulk sequencing misses the rare events and underlying genetic diversity within and across cell populations. The Tapestri Platform is the first and only single-cell platform to simultaneously detect Copy Number Variants (CNVs) and Single Nucelotide Variants (SNVs) from the same cells. To resolve heterogeneity and improve patient stratification, therapy selection, and disease monitoring we need to detect rare clonal populations and identify co-occurrence and zygosity within every single cell.
Single-Cell Sequencing Reveals Clonal Heterogeneity in Acute Lymphoblastic Leukemia.
This webinar will outline a project that performs large-scale and integrative single-cell genome and transcriptome profiling of pediatric acute lymphoblastic leukemia (ALL) cases at diagnosis, during drug treatment, and in case of relapse.
Jan Cools, PhD Professor Genetics KU Leuven, Group Leader VIB