Tapestri Single-cell DNA Myeloid Clonal Evolution Published Panel was designed by the Ross Levine Lab at Memorial Sloan Kettering Cancer Center. The Myeloid Clonal Evolution Published Panel was featured in a study published in Nature, “Single-cell mutation analysis of clonal evolution in myeloid malignancies.” Researchers examined the order of mutation acquisition, impact of co-occurring mutations on clonal fitness and expansion, and correlation between co-mutations and immunophenotypic profiles across clonal hematopoiesis (CH), myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML) by sequencing 740,529 cells in 146 samples from 123 patients with myeloid malignancies.
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Advance your understanding of clonal evolution in a comprehensive set of myeloid disorders by targeting 31 genes with 109 amplicons for single-cell sequencing. The Myeloid Clonal Evolution Published Panel is designed to target the most commonly mutated hospots found to be frequently mutated in human myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML).
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Use Tapestri Designer to add or remove content from existing catalog panels and make this panel your own with content that is relevant to your research. Or start from scratch and upload your human (hg19) or mouse (mm10) targets using gene names, genomic coordinates, or SNV IDs. Target anywhere in the whole human or mouse genome and advance your research with targeted single-cell DNA sequencing.
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