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Myeloid Clonal Evolution Published Panel

Miles, L. A. el al. Nature (2020)

Tapestri Single-cell DNA Myeloid Clonal Evolution Published Panel was designed by the Ross Levine Lab at Memorial Sloan Kettering Cancer Center. The Myeloid Clonal Evolution Published Panel was featured in a study published in Nature, “Single-cell mutation analysis of clonal evolution in myeloid malignancies.” Researchers examined the order of mutation acquisition, impact of co-occurring mutations on clonal fitness and expansion, and correlation between co-mutations and immunophenotypic profiles across clonal hematopoiesis (CH), myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML) by sequencing 740,529 cells in 146 samples from 123 patients with myeloid malignancies.

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Panel Details

Tapestri Single-cell DNA Myeloid Clonal Evolution Published Panel (Levine, MSKCC)

Advance your understanding of clonal evolution in a comprehensive set of myeloid disorders by targeting 32 genes with 109 amplicons for single-cell sequencing. The Myeloid Clonal Evolution Published Panel is designed to target the most commonly mutated hospots found to be frequently mutated in human myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML).

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