Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
X
X
RESEARCHER spotlight
Justin Taylor, MD
University of Miami

Two mutations in RNA splicing factors from the same cell confirmed with single-cell DNA-Seq

Challenging the dogma that single nucleotide variants (SNVs) in RNA splicing factors do not occur in the same cell due to their synthetic lethal interactions and/or convergent effects, Dr. Justin Taylor from the Abdel-Wahab lab at Memorial Sloan Kettering Cancer Center shows that indeed they can. Using Mission Bio’s single-cell sequencing platform, they sequenced close to 100,000 single cells and found instances in which mutations in splicing factors co-occurred within the same cells. Dr. Taylor shares his and his co-authors’ recent publication in the journal Blood, which looks at rare patients with myeloid malignancies with mutations in two RNA splicing genes.

VIEW
RESEARCHER spotlight
Enhance the clinical evaluation of AML MRD by uncovering clonality
Asiri Ediriwickrema, MD
Stanford University
RESEARCHER spotlight
Using CRISPR to understand different combinations of gene alterations
John Lee, MD, PhD
Fred Hutch
RESEARCHER spotlight
Single-cell analysis reveals extensive proteogenomic decoupling in leukemia
Adam Abate, PhD; Ben Demaree; Cyrille Delley
UCSF
RESEARCHER spotlight
How do you decipher and target clonal evolution in myeloid malignancies?
Ross Levine, MD
Memorial Sloan Kettering Cancer Center
REQUEST QUOTE