Leveraging Tapestri’s novel two-step workflow, researchers can resolve the genetic heterogeneity in their complex samples at unprecedented speed and scale. Whether identifying rare subclones missed by standard bulk sequencing, or identifying co-mutation patterns in subclones, Tapestri Single-Cell DNA Panels can be applied across a wide number of applications, including hematologic malignancies, solid tumor profiling, and genome editing programs.

Hematology

Tapestri Single-Cell DNA
Acute Myeloid Leukemia Panel

Advance your understanding of the genetic heterogeneity underpinning acute myeloid leukemia (AML) by targeting 19 genes with 40 amplicons for single-cell sequencing. Covering a combination of oncogenes and tumor suppressor genes, this panel is designed to cover some of the most commonly mutated genes associate with AML.

AML Panel Includes:

  • Reagents and consumables optimized to run on Tapestri
  • Customization of targets available

"In studying leukemias, we are excited about now having the ability to genotype multiple mutations at single-cell resolution in this level of high throughput. Otherwise, the average readout from bulk sequencing misses these important insights in cellular heterogeneity. This new capability of single-cell analysis is critical to better understanding precision therapy selection at diagnosis as well as disease monitoring and subsequent treatment strategy."

- Koichi Takahashi, MD, Assistant Professor

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Tapestri Single-Cell DNA Myeloid Panel

Target SNVs and indels across 47 driver genes with relevant mutations designed to cover a comprehensive set of myeloid disorders including acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML).

Myeloid Panel Includes:

  • Reagents and consumables optimized to run on Tapestri
  • Customization of targets available

Solid Tumor Profiling

Tapestri Single-Cell Tumor Hotspot Panel

Tumor heterogeneity in solid tumor cancers impacts clonal evolution and patient outcomes. Resolve the genomic diversity in a variety of tumors by targeting hotspots across 50 oncogenes and tumor suppressor genes relevant in a range of different solid tumors with SNV and indel mutation detection. Tested with breast, lung, prostate, and colorectal nuclei from fresh frozen tissue samples.

Tumor Hotspot Panel Includes:

  • Reagents and consumables optimized to run on Tapestri
  • Customization of targets available

 

Panel Performance