Chronic lymphocytic leukemia (CLL) is a genetically heterogeneous disease preceded by an asymptomatic expansion of clonal B-cells in a state known as high-count monoclonal B-cell lymphocytosis (MBL). Approximately 1-2% of high-count MBLs evolve into CLL each year. While significant gains have been made in our understanding of genetic mutations that contribute to an aggressive CLL disease state, identifying the biological and genetic events that determine which MBLs will progress to CLL is less understood. By leveraging our Tapestri CLL Panel to gain a better understanding of the clonal evolution that drives the continuum from MBL to CLL, patient prognosis could be predicted long before CLL symptoms occur, and patients could receive regular disease monitoring and earlier treatment.
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Advance your understanding of the genetic heterogeneity underpinning chronic lymphocytic leukemia (CLL) by targeting 32 genes with 274 amplicons for single-cell DNA sequencing. Covering a combination of oncogenes and tumor suppressor genes, the Tapestri CLL Panel is designed to cover some of the most commonly mutated genes associated with CLL.
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Using an AI-powered design, this CLL Panel was developed by our experienced multidisciplinary team. You can expect high panel uniformity, amplicon completeness, and cell completeness from your Tapestri single-cell DNA sequencing experiments.
Use Tapestri Designer to add or remove content from existing catalog panels and make this panel your own with content that is relevant to your research. Or start from scratch and upload your human (hg19) or mouse (mm10) targets using gene names, genomic coordinates, or SNV IDs. Target anywhere in the whole human or mouse genome and advance your research with targeted single-cell DNA sequencing.
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