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Hematology

Because the order of mutational acquisition and MRD detection make a difference.

Gain a deeper understanding of hematological diseases that only single-cell data can uncover, including co-occurrence and zygosity of mutations and clonal evolution. Use single-cell DNA-seq to identify novel biomarkers linked to therapeutic response, resistance, and relapse. In addition, the high sensitivity of rare subclones down to 0.1% allows for detection and monitoring of minimal residual disease (MRD).

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Why Single Cell for Hematology Applications?

For hematological malignancies, particularly myeloid malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations within each cell, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With this information, phylogenetic trees can be reconstructed to determine the clonality underlying the disease and determine the order of acquisition of these mutations. Fish plots show how the clonal architecture changes throughout the course of treatment. And, monitoring during clinical remission poses great promise for novel and sensitive MRD detection.

See how single-cell DNA sequencing applications uncover more informative and actionable data from clinical samples

Track clonal evolution and reconstruct phylogenetic trees
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
- Dr. Koichi Takahashi , MD Anderson Cancer Center
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Reveal therapy resistance mechanisms through course of treatment
Reveal therapy resistance mechanisms through course of treatment
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML
- Dr. Cathy Smith, Dr. Alexander Perl , UCSF, UPenn
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Monitor disease during remission to track MRD
Monitor disease during remission to track MRD
Single-cell mutational profiling enhances the clinical evaluation of AML MRD
- Dr. Ravi Majeti , Stanford
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Hematology Panels

Order a catalog hematology panel or customize any panel with your own targets

Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels for hematologic malignancies based on public databases and actionable clinical targets.

Available Panels
CUSTOM PANELS
Order a catalog panel as is, or easily add or subtract content to customize your research to your specific sequencing applications using Tapestri Designer.
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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + RNA
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DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Solid Tumor
Profiling enables high resolution of the genomic diversity in a variety of tumor types.
Genome Editing
Precision tools provide quality control, ensuring the appropriate edits are incorporated.

Featured Resources

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Use Tapestri Designer to design a custom panel tailored to your needs.

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