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Announcing new Tapestri Platform updates including lowered input threshold and expanded heme-onc menu. Learn More
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Hematologic Malignancies.

Because single-cell insights are critical to determining the source of resistance, response, and relapse

The complexity of cancer is vast, and it is critical to measure the network of biological interactions accurately and minimize inferences. When DNA mutations can be analyzed with protein expression, you can discover clonal networks otherwise obfuscated by bulk methods done in parallel. By connecting genotype to phenotype at the single-cell level, you can gain comprehensive insights into disease progression, development of resistance, and minimal residual disease (MRD).

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NEW: Check out the latest Tapestri Platform updates.

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Why Single Cell for Hematologic Malignancy Applications?

For hematologic malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With these insights, phylogenetic trees can be reconstructed to determine the order of acquisition of these mutations. Fish plots show how clonal architecture changes throughout the course of treatment. And monitoring during remission poses great promise for sensitive MRD detection.

It is time to get a holistic view of cancer

Track clonal evolution and reconstruct phylogenetic trees click to zoom
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics

Dr. Koichi Takahashi, MD Anderson Cancer Center
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Reveal therapy resistance mechanisms through course of treatment click to zoom
Reveal therapy resistance mechanisms through course of treatment
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML

Dr. Cathy Smith, Dr. Alexander Perl, UCSF, UPenn
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Monitor disease during remission to track MRD click to zoom
Monitor disease during remission to track MRD
Single-cell mutational profiling enhances the clinical evaluation of AML MRD

Dr. Ravi Majeti, Stanford
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Hematologic Malignancy Panels

Order predesigned hematologic malignancy panels or customize any panel with your own targets

Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels based on public databases and actionable clinical targets.

Available DNA Panels
Ready-to-Ship
Tapestri Single-cell DNA Catalog Panels
Predesigned and ready-to-ship panels covering the most commonly implicated genes in hematologic malignancies. Wet lab-tested to assure performance.
Acute Myeloid Leukemia
Chronic Lymphocytic Leukemia
Myeloid
NEW: Tapestri Single-cell DNA Published Panels
Predesigned and ready-to-ship panels designed by leading researchers of hematologic malignancies. Featured in peer-reviewed publications from leading research institutes.
Acute Lymphoblastic Leukemia (Jan Cools, VIB)
Myeloid Clonal Evolution (Ross Levine, MSKCC)
Myeloproliferative Neoplasms (Piers Blombery, Peter Mac)
Build-to-Order
Tapestri Single-cell DNA Virtual Design Panels
Predesigned and build-to-order panels for additional indications in hematologic malignancies.
Acute Lymphoblastic Leukemia
Chronic Myeloid Leukemia
Classic Hodgkin’s Lymphoma
Diffuse Large B-Cell Lymphoma
Follicular Lymphoma
Mantle Cell Lymphoma
Multiple Myeloma
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
T-Cell Lymphoma
Tapestri Single-cell DNA Custom Panels
Fully customizable panels for maximum flexibility. Easily order a custom panel using Tapestri Designer.
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Available Protein Panels
Concurrently measure proteins by ordering the ready-to-ship TotalSeq™-D Heme Oncology Cocktail or by configuring your own antibody cocktail from a growing catalog of pre-optimized antibody oligonucleotide conjugates.
TotalSeq™-D Heme Oncology Cocktail from BioLegend
TotalSeq™-D Catalog Antibodies from BioLegend

Hear from a hematological pathologist on how single-cell multi-omics can transform cell therapies for leukemias.

Katherine D. Cummins, M.D., FRACP, FRCPA, University of Pennsylvania

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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

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Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Solid Tumors
Profiling enables high resolution of the genomic diversity in a variety of tumor types.
Genome Editing
Precision tools provide quality control, ensuring the appropriate edits are incorporated.

Featured Resources

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Use Tapestri Designer to design a custom panel tailored to your needs.

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