Gain a deeper understanding of hematological diseases that only single-cell data can uncover, including co-occurrence and zygosity of mutations and clonal evolution. Use single-cell DNA-seq to identify novel biomarkers linked to therapeutic response, resistance, and relapse. In addition, the high sensitivity of rare subclones down to 0.1% allows for detection and monitoring of minimal residual disease (MRD).CONTACT US
For hematological malignancies, particularly myeloid malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations within each cell, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With this information, phylogenetic trees can be reconstructed to determine the clonality underlying the disease and determine the order of acquisition of these mutations. Fish plots show how the clonal architecture changes throughout the course of treatment. And, monitoring during clinical remission poses great promise for novel and sensitive MRD detection.
See how single-cell DNA sequencing applications uncover more informative and actionable data from clinical samples
Order a catalog hematology panel or customize any panel with your own targets
Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels for hematologic malignancies based on public databases and actionable clinical targets.
Custom PanelsCustom designs with Tapestri Designer
Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.
Use Tapestri Designer to design a custom panel tailored to your needs.Contact US