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Hematology.

Because single-cell insights are critical to determining the source of resistance, response, and relapse

The complexity of cancer is vast, and it is critical to measure the network of biological interactions accurately and minimize inferences. When DNA mutations can be analyzed with protein expression, you can discover clonal networks otherwise obfuscated by bulk methods done in parallel. By connecting genotype to phenotype at the single-cell level, you can gain comprehensive insights into disease progression, development of resistance, and minimal residual disease (MRD).

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Why Single Cell for Hematology Applications?

For hematologic malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With these insights, phylogenetic trees can be reconstructed to determine the order of acquisition of these mutations. Fish plots show how clonal architecture changes throughout the course of treatment. And monitoring during remission poses great promise for sensitive MRD detection.

It is time to get a holistic view of cancer

Track clonal evolution and reconstruct phylogenetic trees
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Dr. Koichi Takahashi, MD Anderson Cancer Center
VIEW PAPER
Reveal therapy resistance mechanisms through course of treatment
Reveal therapy resistance mechanisms through course of treatment
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML
Dr. Cathy Smith, Dr. Alexander Perl, UCSF, UPenn
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Monitor disease during remission to track MRD
Monitor disease during remission to track MRD
Single-cell mutational profiling enhances the clinical evaluation of AML MRD
Dr. Ravi Majeti, Stanford
VIEW PAPER

Hematology Panels

Order catalog hematology panels or customize any panel with your own targets

Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted hematology panels based on public databases and actionable clinical targets.

Available DNA Panels
Available Protein Panels
Custom DNA Panels
Order a catalog panel as is, or easily add or subtract content to customize your research to your specific sequencing applications using Tapestri Designer.
DESIGN YOUR CUSTOM DNA PANEL WITH TAPESTRI DESIGNER

Hear from a hematological pathologist on how single-cell multi-omics can transform cell therapies for leukemias.

Katherine D. Cummins, M.D., FRACP, FRCPA, University of Pennsylvania

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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

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Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Solid Tumor
Profiling enables high resolution of the genomic diversity in a variety of tumor types.
Genome Editing
Precision tools provide quality control, ensuring the appropriate edits are incorporated.

Featured Resources

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Use Tapestri Designer to design a custom panel tailored to your needs.

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