Nowell P. The clonal evolution of tumor cell populations. Science. 1976;194:23-28.
Shaughnessy J. Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma. Hematology. 2005;10 Suppl 1:117-26.
Landau DA et al. Clonal evolution in hematological malignancies and therapeutic implications. Leukemia. 2014 Jan;28(1):34-43.
Morita K et al. Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020 Oct 21;11(1):5327.
Miles LA et al. Single-cell mutation analysis of clonal evolution in myeloid malignancies. Nature. 2020 Nov;587(7834):477-482.
Demaree B et al. Joint profiling of proteins and DNA in single cells reveals extensive proteogenomic decoupling in leukemia. bioRxiv 2020.02.26.967133.
App Note: Single-cell DNA analysis with nuclei isolated from solid tumor tissue. Mission Bio.
Gao Y et al. V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. Cancer Discov. 2019 Sep;9(9):1182-1191. Epub 2019 Jun 21.
de Bruin EC et al. Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications. Genome Med. 2013 Nov 22;5(11):101.
Bochtler T et al. Clonal heterogeneity as detected by metaphase karyotyping is an indicator of poor prognosis in acute myeloid leukemia. J Clin Oncol. 2013 Nov 1;31(31):3898-905.
Maia C et al. Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma. Blood. 2020 Jun 25;135(26):2375-2387.
Albert -Servera L et al. Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia. Blood. 2021 Feb 11;137(6):801-811.
ten Hacken E et al. High throughput single-cell detection of multiplex CRISPRedited gene modifications. Genome Biol. 2020;21(1):266. Published 2020 Oct 20.
McMahon CM et al. Clonal selection with RAS pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia. Cancer Discov. 2019 Aug;9(8):1050-1063.
Jongen-Lavrencic M et al. Molecular minimal residual disease in acute myeloid leukemia. N Engl J Med. 2018 Mar 29;378(13):1189-1199.
Landgren O. MRD testing in multiple myeloma: from a surrogate marker of clinical outcomes to an every-day clinical tool. Semin Hematol. 2018 Jan;55(1):1-3.
Ediriwickrema A et al. Single-cell mutational profiling enhances the clinical evaluation of AML MRD. Blood Adv. 2020 Mar 10;4(5):943-952.
Dillon LW et al. Personalized single-cell proteogenomics to distinguish acute myeloid leukemia from nonmalignant clonal hematopoiesis. Blood Cancer Discov. 2021 May 2:1-7.
Gibson CJ, Steensma DP. New insights from studies of clonal hematopoiesis. Clin Cancer Res. 2018 Oct 1;24(19):4633-4642.
Datlinger P et al. Pooled CRISPR screening with single-cell transcriptome readout. Nat. Methods.14, 297–301 (2017).
Dixit A et al. Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screen. Cell. 15;167(7):1853-1866.e17 (2016)
Hill AJ et al. On the design of CRISPR-based single-cell molecular screens. Nat. Methods.15, 271 (2018).
Replogle JM et al. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol. 38, 954-961 (2020).
App Note: Measuring the efficiency of CRISPR genome-editing systems using the Tapestri Platform and Tapestri single-cell DNA custom panels. Mission Bio.
App Note: Tapestri Platform resolves clonality of heterogeneous mouse organoid cancer model through single-cell DNA sequencing of lentiviral barcodes. Mission Bio.
App Note: Single-cell DNA analysis of a novel acute erythroid leukemia (AEL) CRISPR induced mouse model. Mission Bio.
Iacobucci I et al. Modeling and targeting of erythroleukemia by hematopoietic genome editing. Blood. 2021 Jan 19:blood.2020009103.
App Note: In-depth quantification of cell and gene therapy DNA integrations enabled with single-cell sequencing. Mission Bio.
App Note: Deep understanding of cell and gene therapy genome editing protocols enabled with single-cell sequencing. Mission Bio.
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