…Services for the purpose of creating another product or service; or access the Services in order to build a competitive solution or to assist someone else to build a competitive…
…they’re getting sued by the FTC to stop the acquisition. They mentioned all these competitors that are coming up on the sequencing landscape and some new ones that are now…
…and evolutionary trajectories in cancers at the single-cell level and presents his latest findings in breast cancer research. This webinar also presents the latest advances in single-cell DNA sequencing, including…
…researchers with high-throughput, single-cell multiomic analysis of genome-wide CNVs, combined with automated reporting and multiplexing capabilities to ensure even more accessibility. Compared to current methods, the solution equips CGT developers…
…disease lies in its complexity. Tumors are composed of subpopulations of cells — or clones — that each has a unique collection of mutations. It is this heterogeneity coupled with…
Next-generation sequencing (NGS) technology is the gold standard for genomics studies. Although Illumina dominates the NGS market, platforms developed by MGI Tech Co., Ltd. are rapidly growing in popularity. Here,…
Next-generation sequencing (NGS) technology is the gold standard for genomics studies. Although Illumina dominates the NGS market, platforms developed by MGI Tech Co., Ltd. are rapidly growing in popularity. Here,…
…full survey report here: https://go.missionbio.com/cgt-survey-report To learn more about Mission Bio and the Tapestri® Platform, please visit www.missionbio.com. About Mission Bio Mission Bio is a life sciences company…
…so is required or appropriate to: (i) comply with the law or respond to compulsory legal processes or enforceable governmental requests; (ii) verify or enforce compliance with the policies governing…
…more about Mission Bio and the Tapestri Platform, please visit missionbio.com. Media Contact Consort Partners for Mission Bio missionbio@consortpartners.com Mission Bio Announces High Precision Detection of Variants For Tapestri®…
…Anderson Cancer Center, Broad Institute of MIT and Harvard, and St. Jude Children’s Research Hospital embody Mission Bio’s commitment to advancing hematological research. For a complete list of ASH presentations…
…the Genome Editing Consortium. The organization will be working to establish a set of standards in the research and commercialization of the genomics industry, with the aim of increasing confidence…
…research? Browse our free ebook. References App Note: Measuring the efficiency of CRISPR genome-editing systems using the Tapestri Platform and Tapestri Single-Cell DNA Custom Panels. Mission Bio. Iacobucci I et…
…the platform, whether it be fresh or frozen cells, whole cells, or nuclei. Determine the ideal quantity of cells to generate high-quality data. Have fun with the Mission Bio team….
Untangle the Complexity of Cancer. Determine the sources of resistance, response, and relapse Tapestri single-cell DNA panels and protein panels are highly sensitive and customizable panels that enable true multi-omics…
Intricately woven, cancer’s complicated nature hinders true understanding. Within its tightly threaded patterns are answers to your most pressing questions: Where does a new disease state begin? Can I find…
…as Mission Bio’s internal IT security policies. In combination, this offers industry standard data protection and privacy. AWS Security summary Amazon Web Services are recognized to be compliant to current…
…quality control measurements including design and development, release, and documentation processes compliant with the ISO 9001 standard. “Our customers’ success is at the forefront of our mind,” said Adam…
…editing experiments require tools for proper quality control. Single-cell DNA-seq data determines whether on- and off-target edits are being made in the same single cells and reveal every combination of…
…molecule in a cell together, providing a comprehensive understanding of activity from a single sample. Tapestri® is the only commercialized multi-omics research platform capable of analyzing DNA and protein simultaneously…
…labor usage and achieve higher throughput and cost-efficiency without sacrificing quality.” Two new sample multiplexing capabilities allow users to combine and analyze up to three samples per experiment. Sample…
…sample material. This fundamental issue can be a barrier to applying single-cell methods in studies where the sample requirements are simply too high. Mission Bio has heard this call and…
…unmatched resolution, please visit missionbio.com/products/platform/. About Mission Bio Mission Bio is a leading life science company, specializing in the advancement of single-cell DNA and multiomics analysis. The company’s Tapestri…
…relapse. Equipped with single-cell DNA sequencing and other innovative technologies, oncologists and researchers are working hard to bring better treatment to blood cancer patients. References https://www.lls.org/facts-and-statistics/facts-and-statistics-overview https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21654 https://www.medscape.com/answers/199425-167660/what-is-the-prognosis-of-chronic-myelogenous-leukemia-cml …
…level. Using our Tapestri Platform, researchers are performing comprehensive multi-omics analyses and detangling the complexities of diseases, like cancer, at an unprecedented level of detail. Although the day specifically commemorates…
…a single sample — orders of magnitude higher than what is feasible with conventional methods. Simply put, scDNA-seq can considerably reduce the time and effort spent on CGT development. Traditional…
…values asking challenging questions and even harder answers to ensure the best path forward fits both the business needs of the company and the safety of patients. There is a…
Cancer is a complex disease that continuously evolves in response to environmental pressures. The dynamism and heterogeneity of tumors have significant clinical implications. In this eBook, review how single-cell DNA…
…Bio. The company expanded its capabilities, welcomed new leadership, and enabled groundbreaking research. Here are a few of the highlights: 1. Welcoming a New CEO In April Yan Zhang, Ph.D….
…to learn more about Covance Drug Development, visit www.Covance.com. About Argonaut Manufacturing Services Argonaut Manufacturing Services is a cGMP contract manufacturing organization (CMO) dedicated to serving highly innovative companies…
…tissue. Snap freezing or OCT embedding tissues are the most common forms of preservation. However, these methods add an additional layer of complexity to sample preparation. Some researchers have addressed…
…risk factors in myeloma, aiming to differentiate patients at high risk of early relapse from those with prolonged progression-free survival. With access to more immunotherapies and CAR-T bispecifics, if we…
…company’s Tapestri Platform is unique in its capabilities, offering an unparalleled level of granularity and precision that is critical for complex research areas such as cancer studies, pharmaceutical development, and…
…Thank you so much. Interested in hearing more about Dr. Ross Levine’s research? Watch his on-demand webinar. If you are intrigued by single-cell multi-omics, check out our single-cell 101 ebook!…
…generated with the Tapestri Pipeline software to meaningful fish plots using Tapestri Insights. Visualize the thousands of data points intuitively and simply with Mission Bio’s Tapestri Insights software. Part 1/3….
…sciences industry, he brings a unique combination of scientific innovation and strategic business development to the company. His experience in driving organizational transformation and large-scale commercial growth, coupled with his…
…to publish 16 high-quality articles, with the total impact factor exceeding 540 and the average impact factor of a single article reaching 33.8, including international high-level journals such as Cell,…
…single-cell DNA and multiomics analysis. The company’s Tapestri Platform is unique in its capabilities, offering an unparalleled level of granularity and precision that is critical for complex research areas such…
…cancer sample, it’s important to comprehensively measure both DNA mutations and copy number variants in every cell to give us higher resolution to explore tumor evolution and heterogeneity. Gain unprecedented…
…reputation for high-quality GMP compliant assay validation and its client harness Tapestri’s capabilities.” “We are excited to add another state-of-art technology to our biological assay toolkit to support our…
…of the Tapestri platform in our clinical laboratories.” The latest partnership builds on Mission Bio’s commitment to providing high-quality single-cell multi-omics with the Tapestri platform globally, recently demonstrated through a…
…in the journal Nature Medicine, was the latest to demonstrate clinically relevant insights using Mission Bio’s Tapestri® Platform, highlighting rare Richter’s Syndrome subclones that lie dormant for years and could…
…Company’s lead compound, rigosertib, are aimed at what the Company believes are unmet medical needs of patients with MDS. For more information, please visit http://www.onconova.com. About Rigosertib Rigosertib, Onconova’s lead…
…& a Lack of Standardization The FDA requires multiple, different yet complementary assays to show the drug product is pure, safe and potent. However, given the complexity and composition of…
…high-quality living therapeutic cells. Launched in 2017, CMaT aims to revolutionize the treatment of cancer, heart disease, autoimmune diseases and other disorders by enabling broad use of potentially curative…
…as well as reproductive genetics applications. This partnership builds on Mission Bio’s commitment to providing high-quality single-cell multi-omics with the Tapestri platform in China, where there is an increasing demand…
…visit https://go.missionbio.com/ash-2022. To meet us in person, please visit us all week at Booth 2014. To learn more about Mission Bio and the Tapestri® Platform, please visit www.missionbio.com. …
…therapeutic development business. Fulgent’s clinical diagnostic business offers molecular diagnostic testing services, comprehensive genetic testing, and high-quality anatomic pathology laboratory services designed to provide physicians and patients with clinically actionable…
…our knowledgeable field and support team as they tackle any single-cell question in Mission Bio’s Open Office Hours. Get answers to your single-cell technology questions and learn from other users….
…differentiation states that were previously masked. scTAM-seq additionally queries surface-protein expression, thus enabling integration of single-cell DNA methylation information with cell atlas data. In summary, scTAM-seq is a high-throughput, high-confidence…
…build the research protocols and consent and bank specimens from unfortunate tumors that arise, secondary tumors, so that they could be studied with high precision using the tools that we…
…outcomes in the fight against cancer — and that’s the most meaningful benchmark of all.” The funding round comes a year after the company’s commercial launch of the Tapestri Platform…
…To learn more about Mission Bio and the Tapestri® Platform, please visit www.missionbio.com. About Mission Bio Mission Bio is a life sciences company that accelerates discoveries and cures for…
…of single-cell DNA and multi-omic analysis. The company’s Tapestri Platform is unique in its capabilities, offering an unparalleled level of granularity and precision that is critical for complex research areas…
…it was on a good path,” right? We’re starting to see companies come out with that intention specifically to develop targeted therapies, as you mentioned, the complexity of our pharmacologic…
…unique and novel custom panel needs for single-cell DNA or multi-omics panels. This latest milestone comes on the heels of a landmark year for Mission Bio’s work to support…
…fortunate to have had Brittney Le join the Informatics team as an intern for four months. She made many valuable contributions, including improving user guides and producing high-quality video tutorials…
Last week, FDA published draft guidance on Manufacturing Changes and Comparability for Human Cellular and Gene Therapy Products. It’s a great start for an industry that’s been hungry for standardization….
…patient outcomes in the future.” About Mission Bio Mission Bio is a leading life science company, specializing in the advancement of single-cell DNA and multi-omics analysis. The company’s Tapestri…
…world’s leaders in life sciences supporting our commercialization efforts,” says Darrin Crisitello, Chief Commercial Officer of Mission Bio. “Leveraging Agilent’s vast US commercial footprint gives us significant reach to additional…
…solutions to advance research and the deployment of personalized therapy for these debilitating blood cancers.” Mission Bio will host a webinar titled “Myeloma Matters: Advancing Research and Therapy Development…
…be combined or purchased separately to suit the user’s needs. These assays are compatible with the existing Tapestri Instrument, v3 chemistry, and sample multiplexing: Multiple Myeloma DNA Panel, a…
…medicine, announced the commercial launch of the Tapestri® Single-cell MRD (scMRD) AML Multiomics Assay. The company designed the scMRD AML Multiomics Assay to bring unprecedented resolution to disease relapse and…
…You know, that to truly realize personalized medicine, it’s going to really get down to combining multiple measurements at a very, very high resolution platform. So that’s what’s brought me…
…analysis at speed and scale orders of magnitude higher than prior methods. The study, published in Genome Research and co-authored by researchers at Mission Bio and MD Anderson Cancer Center,…
…(October 29, 2020) Mission Bio, Inc. today announced the launch of a complete Tapestri® Single-cell Multi-omics Solution, the most comprehensive single-cell multi-omics platform on the market. With a new instrument,…
Inactive state-selective KRAS(G12C) inhibitors1-8 demonstrate a 30-40% response rate and result in approximately 6-month median progression-free survival in patients with lung cancer9. The genetic basis for resistance to these first-in-class…
…targeted solution for high impact applications. The company also announced its expansion into Europe, rolling out regional sales alongside partnerships with three key research institutions: VIB in Flanders, Belgium, the…
…conferences. CASSS: Bridging Biopharma and Regulatory Bodies At the CASSS CGPT Meeting, the presence of both biopharma companies and regulatory bodies highlighted a critical need for comprehensive characterization data. The…
Despite insights gained by bulk DNA sequencing of cancer it remains challenging to resolve the admixture of normal and tumor cells, and/or of distinct tumor subclones; high throughput single-cell DNA…
…To learn more about Mission Bio and how it’s moving precision medicine forward, visit www.missionbio.com. About Mission Bio Mission Bio delivers targeted solutions for high impact applications with the…
…of residual or recurring cancer.” To learn more about Mission Bio and the Tapestri® Platform, please visit www.missionbio.com. About Mission Bio Mission Bio is a life sciences company…
…ways of treating patients and advancing precision therapeutics.” To learn more about Mission Bio and the Tapestri platform, please visit www.missionbio.com. About Mission Bio Mission Bio is a life sciences…
…leading research centers, pharmaceutical, and diagnostics companies worldwide to develop treatments and eventually cures for cancer. Media Contact Consort Partners for Mission Bio missionbio@consortpartners.com New Study in Nature Cardiovascular Research…
…day come to be? As many of us are familiar, when it comes to participation in science there is a rift between the genders. Only about a third of scientific…
…Dr. Koichi Takahashi and team from MD Anderson highlighted the application power of Tapestri by presenting the first single-cell atlas of acute myeloid leukemia in the largest clinical research study…
Many stages of hematopoietic differentiation provide multiple opportunities for mutations that lead to distinct tumor subtypes. However, standard bulk population sequencing is hard to identify rare alleles or determine whether…
Genome engineering techniques, like CRISPR, have revolutionized how scientists approach research and precision therapeutics. While a powerful technique, especially for engineering novel therapeutics, CRISPR introduces some inherent challenges related to…
…production of cell and gene therapies (CGTs) is highly variable and presents unique challenges in characterization. We wanted to understand how current CGT developers are grappling with these new hurdles…
…correlating DNA and immunophenotype at the single-cell level across disciplines – ranging from HIV research to gene and cell therapy clinical quality attribute measurement.” The paper, “Phenotypic signatures of…
…and diagnostics companies around the world to develop treatments and eventually cures for cancer. To learn more, visit missionbio.com. Media Contact: Consort Partners for Mission Bio missionbio@consortpartners.com A New…
…eventually cures for cancer. To learn more, visit missionbio.com. Media Contact Consort Partners for Mission Bio missionbio@consortpartners.com New Nature Medicine Publication Highlights Battle of the Clones in Pediatric MDS…
…method for investigating DNA methylation dynamics at single-cell and single-nucleotide resolutions scTAM-seq enables DNA methylation assessment with high accuracy, achieving a false-positive rate lower than 0.2% combined with a false-negative…
…of the Centre for Genomic Regulation (CRG) in Barcelona teamed up to develop a novel high-throughput, high-confidence targeted bisulfite-free method for analyzing DNAm in single cells, now published in Genome…
…Bio and the Tapestri® Platform, please visit www.missionbio.com. About Mission Bio Mission Bio is a life sciences company that accelerates discoveries and cures for a wide range of diseases…
Tapestri is a high-throughput single-cell genomics platform that plugs into your workflow to identify co-occurring mutations, measure zygosity, and detect rare cell populations. With the Tapestri Platform, you can monitor…
…a cell together, providing a comprehensive understanding of activity from a single sample. Tapestri is the only commercialized multi-omics platform capable of analyzing DNA and protein simultaneously from the same…
…the current workflow. With this latest capability, Mission Bio’s Tapestri® Platform now stands as the first and only commercial platform for single-cell DNA analysis, with comprehensive insight into mutations and…
Adds to growing body of research probing the undescribed mechanisms of resistance to targeted therapies SOUTH SAN FRANCISCO, March 8, 2021 — Mission Bio, the life sciences company delivering…
…do so, Buyer must promptly notify Seller of such Improvement and offer Seller the exclusive right to undertake such manufacture, use, sale, commercialization, or exploitation under commercially reasonable terms, which…
…or without MDS-PA at diagnosis, respectively. Noteworthy, MDS-associated mutations infrequently emerged after high-dose therapy. Based on MFC profiling, patients with MDS-PA have altered hematopoiesis and T regulatory cell distribution in…
…bulk sample analysis. With proprietary microfluidic droplet technology, Mission Bio is developing research tools that allow high-throughput, single-cell nucleic acid characterization across a variety of research applications, including oncology and…
…Composite complete remission with IVO + VEN + AZA versus IVO + VEN was 90% versus 83%. Among measurable residual disease (MRD)–evaluable patients (N = 16), 63% attained MRD-negative remissions;…
…stores on the weekends. In my free time, I enjoy dancing, working out, painting, and attending concerts. Why did you decide to do an internship in biotechnology? I was originally…
…life science research, healthcare, and agriculture. For more information about S2 Genomics and the Singulator 100, visit www.S2Genomics.com. Media Contact Consort Partners for Mission Bio missionbio@consortpartners.com Mission Bio…
Despite insights gained by bulk DNA sequencing of cancer it remains challenging to resolve the admixture of normal and tumor cells, and/or of distinct tumor subclones; high-throughput single-cell DNA sequencing…
…of TIBSOVO resistance supported clinical findings of the pivotal TIBSOVO-azacitidine combination trial in IDH1-mutant AML, and the combination was approved by FDA in May 2022. Partnership will continue to generate…
…screens, and gene-edited based cell and gene therapies. With the ability to provide high-throughput analysis at single-cell resolution, this innovative solution is a game-changer through its comprehensive, multi-omic approach. The…
…that ultimately should provide higher accuracy when detecting relapse. Multiple Myeloma Complexity Complicates Treatment When deciphering complex diseases like Multiple Myeloma, it can be difficult due to competing clones –…
…a significant proportion of patients in complete remission subsequently relapse and succumb to the disease. Measurable residual disease (MRD) testing has become the standard in AML and other cancers to…
…but also identify putative DNA or protein targets for salvage therapy. By combining high sensitivity with multiomics, this assay provides researchers with comprehensive and clinically actionable insights into AML MRD….
…Genome Editing Solution, enabling researchers to conduct more comprehensive analysis of genome editing outcomes that also includes on- and off-target edit confirmation, zygosity, and co-occurrence of edits at single-cell resolution….
…the co-founders came with it. But I was looking for the right founding team and co-founders, who could either come into the company or continue supporting the company in an…
…The online version of the full peer-reviewed study can be found here. To learn more about Mission Bio and how it’s moving precision medicine forward, visit www.missionbio.com. About Mission…
During the course of infection, human immunodeficiency virus (HIV) maintains a stably integrated reservoir of replication-competent proviruses within the host genome that are unaffected by antiretroviral therapy. Curative advancements rely…
…to treat is that the disease inherently has many different molecular drivers and indicators. MM is a genetically complex malignancy comprised of immunoglobulin translocations, focal and genome-wide CNVs, complex genomic…
Research Background Acute myeloid leukemia (AML) is a complex disease with a diverse genetic landscape, leading to treatment challenges and frequent relapses. Measurable residual disease (MRD) testing has become a…
Acute myeloid leukemia (AML) is a complex disease with a diverse genetic landscape, leading to treatment challenges and frequent relapses. Measurable residual disease (MRD) testing has become a standard in…
Researcher Spotlight Women in Single-Cell Series We recently featured Dr. Ilaria Iacobucci, Ph.D. from the St. Jude Children’s Research Hospital in our Women in Single Cell webinar series. Ilaria’s research…
…missed by standard bulk sequencing or identifying co-mutation patterns and zygosity in subclones, Tapestri Single-cell DNA panels and protein panels can be applied across a wide range of discovery and…
…resolution of the disease at the cellular level, revealing the interplay between genotype and phenotype. The Tapestri Platform enables comprehensive identification of cell subpopulations through single-cell multi-omics profiling. The platform…
…takeaways from this application note include: • Mission Bio’s Nuclei Extraction Protocol works effectively for fresh frozen breast cancer samples and can generate high-quality single-cell DNA data. • Tapestri Single-cell…
…takeaways from this application note include: • Mission Bio’s Nuclei Extraction Protocol works effectively for fresh frozen breast cancer samples and can generate high-quality single-cell DNA data. • Tapestri Single-cell…
Sequencing has revolutionized cancer research – are you still just using bulk sequencing? What are you missing? Find out about the latest and greatest work in single cell DNA sequencing…
…inherently complex, posing new challenges that may impact therapeutic effectiveness and safety. Of note, there have been several recent delays to product approvals and clinical holds on various late-stage CGTs…
In this virtual seminar, Dr. Sandra Misale of Memorial Sloan Kettering Cancer Center presents data from her latest publication “Molecular characterization of acquired resistance to KRAS G12C inhibition in gastrointestinal…
…Institute of Standards and Technology (NIST) Genome Editing Consortium includes experts across academia, industry, and government to collaboratively address genome editing measurements and standards needed to increase confidence in evaluating…
…Complexity of CRISPR CRISPR technology has undeniably transformed genetic research and is ushering in a new era of cell and gene-based therapeutics, including the recently FDA-approved Casgevy drug to target…
At Mission Bio, we’re committed to improving cancer research and care, supporting the development of more precise, impactful therapies and, ultimately, saving patients’ lives. We have an established history of…
…Thank goodness the content will be available until June for continued viewing. As Mission Bio’s customers span all aspects of translational research, I wanted to hear the latest on prognostic…
…a wide breadth of topics – bringing together the cancer research community to inspire innovation and build knowledge, connections and collaborations. We enjoyed inspiring scientific communications at our booth and…
…with those who communicate like you, and those who communicate in ways that are the exact opposite to you. Erin: What is different about Mission Bio’s Women’s group? Samantha: When…
With the latest additions and improvements to Tapestri’s capabilities, researchers of hematologic oncology can now access single-cell insights from as few as 20,000 cells, while conserving precious samples. Get up…
…edit, off-target edits, translocations between predicted edit sites, as well as the genomic CNV landscape in over thousands of cells in parallel. This single-cell technology offers a comprehensive view of…
…to Tapestri while highlighting the power of the GE solution. The combination of these two innovative solutions creates an indispensable tool that equips researchers to unravel the intricacies of genome…
…The company has partnered with BioLegend, a global leader in protein antibody and reagent manufacturing, to co-develop the first commercial solution for combined DNA and protein analysis at the single-cell…
Hematology. Because single-cell insights are critical to determining the source of resistance, response, and relapse It is time to get a holistic view of cancer The complexity of cancer is…
Find the key signatures of cancer. Cancer is a complex disease, where behind its complexity lie meaningful insights to source and its cure. Bulk sequencing erases cancer’s fundamental units, individual…
…can unravel the mechanisms that drive disease correction and disease progression, visit missionbio.com. ———————————————————————– 1 https://www.cancer.gov/research/key-initiatives/ras/about About Mission Bio Mission Bio is a life sciences company that accelerates discoveries…
Immunohistochemistry (IHC) has been the gold standard to determine if a patient is in remission, but laboratories are transitioning into RT-PCR for fusions and flow cytometry for greater depth of…
…followed by re-introducing the modified T-cell back into patients, the quality of CAR-T is extensively regulated. Key safety and efficacy attributes such as transduction efficiency and transgene copy number, or…
…selection committee really enjoyed talking with the applicants and learning how they would apply Mission Bio’s technology of single-cell DNA sequencing to answer their research questions. The applicants spanned a…
Untangle the complexity of cancer with true multi-omics. Gain the true single-cell picture to enable precise understanding The Tapestri Platform is the only system capable of simultaneously providing both genotype…
…He discusses NGS library prep and sequencing of single-cell DNA libraries. Learn tips and tricks from our team of experts on how to obtain high-quality data from single-cell DNA sequencing…
…genetic alterations of a patient’s T cells by introduction of the CAR into host cells using lentiviral vectors, the quality of CAR T cell therapies are extensively regulated to warrant…
Understanding tumor heterogeneity and clonal evolution has major implications in oncology research. Both chromosomal structural change/copy number alteration/variation (CNA/CNV) and driver gene mutation events are critical in cancer initiation and…
…in targeted therapy selection and disease monitoring. Single-cell sequencing has the potential to provide unique insights on the cellular and genetic composition, drivers, and signatures of cancer at unparalleled sensitivity….
Bulk NGS using archived solid tumor samples is inadequate to fully characterize somatic variation buried in the landscape of cellular populations. Single-cell targeted DNA sequencing provides an essential solution to…
Single-cell technologies have advanced our approach to precision medicine, improving our understanding of the genetic variation and drivers of cancer with sensitivity that bulk sequencing cannot provide….
…date. With Mission Bio, researchers have a highly sensitive, targeted, and customizable solution to move precision medicine forward. Media Contact: Kathryn Ryan VSC for Mission Bio missionbio@vscconsulting.com (631) 255-5281…
Former Thermo Fisher Scientific exec to lead next phase of growing single-cell multi-omics company SOUTH SAN FRANCISCO, April 8, 2021 — Mission Bio, the pioneer in high-throughput single-cell DNA…
…into existing NGS workflows. With Mission Bio, researchers have a highly sensitive and customizable solution that is fully supported to enable meaningful discoveries. missionbio.com twitter.com/MissionBiolinkedin.com/company/3882975/ Media Contact: Andrea Vuturo andreahawleypr@gmail.com…
Solid Tumor. Because clonal phylogeny and rare cell detection contribute to disease evolution It is time to look at the sources of maligancies Solid tumors often show multiple levels of…
…our strategy is to support companies developing cutting edge science that has significant potential to positively impact patients and society. Single-cell analysis has proven highly valuable in cancer research, and…
… Darrin Crisitello joins the Mission Bio team as Chief Commercial Officer with over 19 years of experience in commercial leadership and business development. Previously, Crisitello led the global clinical…
…concern, the pressing need for effective SCD treatments urges continued research, monitoring, and careful consideration of the benefits against the risks in advancing such transformative therapies. Sources https://www.genengnews.com/topics/genome-editing/crispr-prime-time-fda-advisory-committee-evaluates-vertex-exa-cel-therapy-for-sickle-cell-disease/ https://endpts.com/uk-approves-vertex-crispr-therapy-for-sickle-cell-disease-beta-thalassemia-in-world-first/…
…building high-growth companies. His prior roles include founder, CEO, executive board director, division president at large publicly traded and PE-backed companies such as Fortis Life Sciences, LGC, PerkinElmer, Life Technologies,…
…advanced filters are used to evaluate the following metrics: – Genotype quality – Read depth – VAF for mutant GT calls – Percentage of cells with GT present – Percent…
…the team has itself leveraged Tapestri as a quality control method for its genome-editing research, analyzing the off-target effects of CRISPR for therapeutic development. Now, Tapestri’s single-cell capabilities will complement…
…adhering to safety and health guidelines. Join a discussion with our leaders from Manufacturing and Quality to hear about some of the things we are considering before we re-open our…
…Women across all departments — from R&D to the commercial team— are a key reason why the company is rapidly developing single-cell solutions for cutting-edge cancer research. We continue to…
…pharmaceutical companies are now investigating combinatorial therapies to target co-occurring mutations and prevent therapeutic resistance. Mission Bio’s Pharmaceutical Assay Development offering can help in these studies. They also have expertise…
…are few financial incentives for pharma companies to develop drugs to treat them. Recognizing the need in 1983, Congress passed the Orphan Drug Act to create incentives for companies to…
…during complete remission and uncovered complex clonal evolution within AML tumors that was not observable with bulk sequencing. We anticipate that this approach will make feasible the routine analysis of…
CRISPR-Cas9 gene editing has transformed our ability to rapidly interrogate the functional impact of somatic mutations in human cancers. Droplet-based technology enables the analysis of Cas9-introduced gene edits in thousands…
…samples reveals underlying evolutionary process of therapeutic resistance. Together, these data unravel clonal diversity and evolution patterns of AML, and highlight their clinical relevance in the era of precision medicine….
…progression and develop more precise therapies. The commercial launch of Mission Bio’s Tapestri Solution for Solid Tumor Research highlights the company’s continued dedication to enabling cancer research at a…
…with the ability to deeply profile thousands of individual cells for a rich characterization of tumor evolution and heterogeneity. This must be done at a much higher resolution compared to…
…research organizations, and biopharma companies can utilize the scMRD assay for AML for proof-of-concept study research programs ahead of full-scale commercialization. For more information, visit https://go.missionbio.com/scMRD-AML-EA. [1] Relapse in…
…Anderson Cancer Center. “Tapestri overcomes the throughput limitations and workflow complexities associated with other single-cell methods and offers highly specific and reproducible results. Not only can we now better understand…
…clonal trajectories for each sample and uncovered combinations of mutations that synergized to promote clonal expansion and dominance. Finally, we combined protein expression with mutational analysis to map somatic genotype…
To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at…
…complex genotype-phenotype dynamics that illustrate the subtlety of the disease process and the degree of incongruity between blast cell genotype and phenotype in different clinical scenarios. Our results highlight the…
…acquired resistance to IDHi, along with BCOR, homologous IDH gene, and TET2. These data suggest that targeting stemness and certain high-risk co-occurring mutations may overcome resistance to IDHi in AML….
Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein expression, metabolomic and methylation…
…unknown. We characterized the whole genome, epigenome and transcriptome, combined with single-cell DNA/RNA-sequencing analyses and functional experiments, of 19 cases of CLL developing RT. Studying 54 longitudinal samples covering up…
Adam is a co-founder and the interim Chief Operating Officer of Mission Bio. His proprietary research in high throughput and droplet technology helped lay the foundation for Mission Bio’s single-cell…
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel…
…readouts and separately for characterization of editing outcomes through pooled single-cell genotyping. We efficiently design improved leukemia immunotherapy approaches, comprehensively identify non-coding variants modulating fetal hemoglobin expression, define mechanisms regulating…
…vital importance of science. At Mission Bio, we remain steadfast in our mission to help researchers unravel the complexity of cancer, and we applaud the cancer research that was accomplished…
…single-cell DNA sequencing, on the other hand, can be used to dissect tumor architecture with a high amount of detail — including zygosity, co-mutations, and clonal composition. This study adds…
…with very low VAF (0.1%). Because the assays are targeted (there is high read depth per amplicon region), rare variants are captured with high confidence. Due to its high sensitivity,…
…multiplex-PCR-based targeted DNA sequencing approach. The platform demonstrates high-sensitivity detection of SNVs and indels in the same cells and generation of high-resolution maps of clonal architecture based on mutational profiling….
…obtain a comprehensive, high-resolution view of the clonal evolution of T-ALL, researchers at VIB-KU Leuven Center for Cancer Biology leveraged Mission Bio’s Tapestri Platform and a Tapestri custom DNA panel…
…technology, Mission Bio is developing research tools that allow high-throughput, single-cell nucleic acid characterization across a variety of research applications, including oncology and immunology. Media Contact: Andrea Vuturo 847-772-2205 andreahawleypr@gmail.com…
…next stage of collaborative research.” Through its centers of excellence, Mission Bio is partnering with leaders within the solid tumor research community as it continues to build and refine Tapestri’s…
…at leading research centers, pharmaceutical, and diagnostics companies worldwide to develop treatments and eventually cures for cancer. Media Contact Consort Partners for Mission Bio missionbio@consortpartners.com Stuart Essig Named as New…
…the pioneer in high-throughput single-cell DNA and multi-omics analysis, today announced a new Center of Excellence, located at the Josep Carreras Leukaemia Research Institute and led by Manel Esteller, MD,…
…Move beyond the average readout from conventional bulk sequencing, and uncover the underlying heterogeneity and rare cell populations in cancer research samples. The average readout from conventional bulk sequencing misses…
Single-cell sequencing is like looking at the galaxy with the Hubble telescope. It provides the ability to drill down into the complexity of a cell in an environment where each…
DNA is the template for human biology and the point where a single mutation initiates disease. By taking a holistic approach, we can investigate every part of the cell and…
…physics and applied it to droplet manipulation, ultimately co-developing the technology that became the core of Mission Bio. He continues to be interested in tackling complex, interdisciplinary problems with physics….
…roadmaps, business partnerships, and customer success programs in research and clinical markets. Previously, she held leadership positions at IONpath and Advanced Cell Diagnostics. She received a Master of Science in…
George began his career as a research scientist at Pfizer and later moved to the tools side of the life sciences industry. Over the past 20 years, George has had…
Hannah Viernes leads the marketing team and has over 15 years of experience across life sciences tool companies in both product management and marketing. Most recently, Hannah led the Global…
…Thanks to an enormous endeavor by the research community to identify the factors that underlie the onset, progression, and relapse of AML and concurrent advances in biotechnologies, many breakthroughs have…
Vascular malformations are considered monogenic disorders that result in dysregulated vessel growth. Cerebral cavernous malformations (CCMs) arise owing to inactivation of the endothelial CCM protein complex required to dampen MEKK3…
…alterations and increased sensitivity to extracellular signal-regulated kinase inhibition. These findings identify an approach that abrogates the nongenetic resistance trajectory in melanoma and demonstrate that the cellular composition of MRD…
Ben Schroeder has over 20 years of experience in biotechnology R&D. His focus has been novel genomic technologies spanning small start-ups to large established companies. Ben started his career at…
Marlene Martinez leads the human resources team focusing on attracting, retaining, and developing our talent as we scale as an organization. She has over 15 years of experience in human…
…bone marrow single-cell DNA sequencing revealed multiple competing SGR events in individual patients. Our findings demonstrate that SGR is common in SAMD9/9Lmut MDS and exemplify the exceptional plasticity of hematopoiesis…
…B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar accumulation of random…
…develop a single custom targeted panel for high-throughput scDNA-seq using a microfluidics platform. We applied MPT to profile 330 mutations across 23,500 cells from 5 TNBC patients, which showed that…
…familial CCM. Furthermore, we find identical PIK3CA mutations in CCMs and adjacent developmental venous anomalies (DVAs), a common vascular malformation frequently found in the vicinity of sporadic CCMs. However, somatic…
…research program focused on improving molecular diagnostics for a variety of cancers, but specifically myeloid leukemia. He has published over 60 peer reviewed manuscripts, patented error-corrected NGS methods to improve…
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low…
…precursors remains a challenge with current MRD tools. Herein, we developed a single cell (sc) MRD assay by combining flow cytometric enrichment of the targeted precursor/blast population with integrated scDNA…
…a phenotypic signature primarily characterized by upregulation of surface markers promoting cell survival, including CD44, CD28, CD127 and the IL-21 receptor. Together, these results suggest compartmentalized phenotypic signatures of immune…
…base editing mutagenesis. Deep mutagenesis of JAK1 with cytidine and adenine base editors, combined with pathway-wide screens, reveal loss-of-function and gain-of-function mutations, including causal variants in hematological malignancies and mutations…
Recent data suggest that NPM1-mutated AMLs are heterogeneous in terms of co-mutations and expression of transcriptomic programs and surface proteins. Such heterogeneity may reflect a variable differentiation blockade of leukemic…
…or are not applicable to targeted sequencing. Here, we develop COMPASS, a computational method for inferring the joint phylogeny of SNVs and CNAs from targeted scDNAseq data. We evaluate COMPASS…
Roman is the Chief Commercial Officer at Mission Bio. Roman has more than 25 years of experience in diagnostics and life sciences research, including previous roles as EVP and General…
…current treatment paradigm by combining novel therapies to prevent or delay resistance to these novel agents.” These insights underscore the power of single-cell DNA analysis to provide high-resolution monitoring…
…high accuracy and resolution. Meet the Tapestri® Genome Editing Solution The Tapestri Platform uses microfluidics to isolate single cells and perform targeted DNA sequencing. Tapestri enables high-throughput and high-resolution…
…perform single-cell vector copy number (VCN) and transduction measurements simultaneously– including VCN per transduced cell, providing more accurate characterization within a cell population compared to bulk measurements. This comprehensive analysis…
…in Melbourne, Australia, highlights co-occurring therapy-driven mutations that stand to impact future treatment strategies and combinatorial approaches. The findings were published in Blood, the peer-reviewed medical journal of The American…
…7973 cells per sample. Nine of the 12 cases showed at least 1 subclonal mutation, of which cases with PAX5 alterations or high hyperdiploidy (with intermediate to good prognosis) showed…
Internal tandem duplication of the Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3-ITD) is one of the most clinically relevant mutations in acute myeloid leukemia (AML), with a high FLT3-ITD…
…immunophenotypic markers. This high-resolution, single cell assay offers a potential new modality for the diagnosis and surveillance of patients with suspected MGUS, SGUS or high-risk MM. We have demonstrated: 1)…
…MM heme/therapeutic markers. This high-resolution, single cell assay offers a potential new modality for the diagnosis and surveillance of patients with suspected MGUS, SGUS or high-risk MM. We have demonstrated…
…of precision medicine,” said Ursheet Parikh of Mayfield Fund. “With their unique approach combining precision engineering with cutting-edge biochemistry, we see the opportunity to greatly impact the economics and success…
…data resolves the complexities of mutation zygosity and co-occurrence in a genome-editing experiment targeting multiple loci. The Tapestri Platform offers a turnkey solution to the complex challenge of characterizing genome-edited…
Recent advancements in genomic analysis of tumors have revealed that cancer disease evolves by a reiterative process of somatic variation, clonal expansion, and selection. To identify lower-prevalence mutations, very high-level…
Co-occurrence and zygosity of mutations in subclonal populations are frequently missed with bulk sequencing. In high-count monoclonal B-cell lymphocytosis (MBL), these mutations were detectable across all patient samples, on average…
…Platform provides the most sensitive and nuanced quantification of genetic edits made to single cells with a simple one-day high-throughput workflow. In this app note, we demonstrate the workflow and…
…co-mutations responsible for tumorigenesis. The following are covered: Assessment of precise genetic edits Analysis of the clonal structure & co-mutations of AEL Use of CRISPR and scDNA-seq for disease modeling…
…every molecule in a cell together, providing a comprehensive understanding of activity from a single sample. Tapestri is the only commercialized multi-omics platform capable of analyzing DNA and protein simultaneously,…
…research centers, pharmaceutical, and diagnostics companies worldwide to develop treatments and eventually cures for cancer. To learn more, visit missionbio.com. Media Contact Consort Partners for Mission Bio missionbio@consortpartners.com Tapestri Cell…
…interrogate every molecule in a cell together, providing a comprehensive understanding of activity from a single sample. Tapestri is the only commercialized multi-omics platform capable of analyzing DNA and protein…
…commercialized multi-omics platform capable of analyzing DNA and protein simultaneously from the same sample at single-cell resolution. Tapestri® is utilized by customers at leading research centers, pharmaceutical, and diagnostics companies…
…growth. “Single-nuclei DNA sequencing using Tapestri was central to our research, giving us a definitive view that the combination of these mutations occurring in the same cells drives aggressive…
…around the globe the power to interrogate every molecule in a cell together, providing a comprehensive understanding of activity from a single sample. Tapestri is the only commercialized multi-omics platform…
…Mission Bio and how its Tapestri Platform is helping enhance cancer and rare disease research and unlock pathways to new treatments, please visit missionbio.com. About Mission Bio Mission Bio is…
…of multiple concurrent mechanisms in individual patients underscores the complex biology of resistance and has important implications for rational combination therapy design. This trial was registered at www.clinicaltrials.gov as #NCT02074839….
…sciences professionals about how diverse and inclusive they feel their industry is. See how the Women of Mission Bio are supporting each other in last week’s blog. References https://www.aauw.org/resources/research/the-stem-gap/ …
Covalent (irreversible) Bruton’s tyrosine kinase (BTK) inhibitors have transformed the treatment of multiple B-cell cancers, especially chronic lymphocytic leukemia (CLL). However, resistance can arise through multiple mechanisms, including acquired mutations…
…cellular compartments depending upon co-occurring mutations. These studies provide a path to model sequential mutagenesis and deterministically investigate mechanisms of transformation and oncogenic dependency in the context of clonal evolution….
…MIF modifies TET2 CH cardiovascular disease risk. Using mitochondrial lineage tracing, we used a novel method to compare gene expression between mutated and non-mutated cells within individual CH patients. We…
…role in hematopoietic stem cell differentiation and monocyte lineage commitment. Together, these data provide a mechanistic insight to the poor prognostic value of clonal hematopoiesis in patients infected with Sars-COV2….
…cancers, acute myeloid leukemia (AML) is a highly heterogeneous disease. Tumors are often composed of cells with different combinations of mutations and genetic alterations. They are also phenotypically diverse, with…
…least 1 subclonal mutation, of which cases with PAX5 alterations or high hyperdiploidy showed a high number of subclones at diagnosis, defined by a variety of alterations in the JAK/STAT,…
…target cells. This involves assessing the precision and accuracy of the intended genetic modifications and identifying any off-target effects. These measurements are more complicated to uncover, given the heterogeneity of…
…cells, providing a comprehensive view of cell engineering. Streamline Complex Analyses: The automated Solution generates intuitive data reports for interpreting single-cell data. Check out an example report. Enhancing Patient…
…cell populations at unprecedented resolution compared to traditional bulk sequencing approaches. Starting the design process is easy, and panel designs can be completed within a matter of minutes. To begin,…
Darrin Crisitello, Chief Commercial Officer, Mission Bio At Mission Bio, everyone at the company is pushing forward with science that can improve patient care in a meaningful way. Upon recently…
High-throughput single-cell DNA sequencing is essential to assess genetic variations in rare cells and better understand the role they play in the evolution of tumor progression. To address these challenges…
High-throughput single-cell DNA sequencing allows for the detection of rare mutations in cells and identification of sub-clones defined by co-occurrence of mutations. The big challenge with multiplex sequencing at the…
High throughput single cell DNA targeted sequencing enables the detection of rare mutations in cells and the identification of subclones defined by co-occurrence of mutations. The big challenge with multiplex…
…is helping to unravel the complexity of cancer, visit missionbio.com. About Mission Bio Mission Bio delivers targeted solutions for high-impact applications with the Tapestri Platform. The Tapestri Platform is…
We recently spoke with Dr. Smith about her research, use of the Tapestri Platform, and thoughts on the clinical potential for routine, high-throughput single-cell DNA analysis….
…For the first time, investigators can now, in a high-throughput fashion, garner genomic and proteomic information from thousands of single cells by adding a simple cell staining protocol with antibody-oligo…
…genetic composition. This poster presents the process of Mission Bio’s Tapestri Platform, which enables high-throughput targeted DNA sequencing in single cells to obtain single-nucleotide variation (SNV) and copy number variation…
…Platform provides the most sensitive and nuanced quantification of genetic edits made to single cells with a simple one-day high-throughput workflow. In this app note, we demonstrate the workflow and…
…on both the sensitivity and specificity of commercial MRD tests used today both in research and to predict cancer recurrence in patients, leveraging the Tapestri® Platform’s unique ability to measure…
…patients, we defined 4 distinct clusters. Cluster 4, characterized by more complex subclonal structure correlated with reduced overall survival, independent of the MPN subtype, presence of high molecular risk mutations,…
…aspects of therapy characterization. The Tapestri Platform enables multiple genotypic and phenotypic attributes to be co-measured across 1000s of individual cells. This high-throughput platform collapses multiple assays into one workflow,…
Single-cell DNA sequencing on the Tapestri Platform provides a high-resolution analysis of gene-edited cells, including on-/off-target editing, multiplex edits, zygosity, and chromosomal aberrations. For projects that involve gene transfer and…
…to estimate vector copy number (VCN) and characterize somatic variants in the cell population. Taken together, a high throughput single-cell multi-omics platform enabled us to simultaneously identify somatic variants along…
…MRD across thousands of individual cells, providing clonal insight in tandem with immunophenotype from rare residual disease cells. These high-resolution, integrated molecular profiles bring unprecedented clarity to the complex biology…
Mission Bio’s Tapestri® Genome Editing Solution offers a comprehensive solution for high-throughput analysis of genomic edits at single-cell resolution. Here, we showcase the robust performance of the pipeline for both…
Cancer is a heterogeneous mixture of cells with varied states. The best treatment options require an understanding of the disease state at the cellular level. Single-cell multi-omics reveals the interplay…
…only be achieved through single-cell analysis and is critical for informed clinical research. Learn how to obtain both CNVs and SNVs from the Tapestri Platform using Tapestri Single-cell DNA Panels….
Genomics data alone provides only partial insights into the cell’s type, state, or function. To obtain a more complete picture and reveal the cell’s phenotypic character, a single-cell multi-omics approach…
The use of genetically engineered model organisms is valuable in advanced preclinical oncology research for disease progression and drug development. Bladder cancer is caused by upwards of 5 mutations or…
An average readout from conventional bulk sequencing misses the underlying genetic diversity across cell populations. The Tapestri Platform was developed to enable the accelerated and accessible detection of genomic variability…
…a more comprehensive picture of the disease progression. Distinguishing mutational status at the single-cell level offers precision in diagnosis and informs treatment options. Learn how the Tapestri Single-cell DNA AML…
The Tapestri Platform measures transduction efficiency in 1000s of individual cells without the need for clonal outgrowth. This approach allows for the rapid optimization of gene transfer protocols during therapy…
…peer-reviewed study validating the technology that powers our Tapestri Platform. The study marks the first-ever application of a commercial high throughput single-cell DNA sequencing technology to patient samples. Together, MD…
…pleased to partner with BioLegend to co-develop the first commercial solution for true multi-omics at the single-cell level. Biolegend is a market leader in providing protein antibodies to the research…
…world. With the leading platform for single-cell multimodal omics, Mission Bio is on a mission to enable the cancer research community to find cures for cancer. Happy new year, and…
…reduced effects on RNA splicing and/or binding compared with the most common alleles. Moreover, dual U2AF1 mutations occurred in cis with preservation of the wild-type allele. These data highlight allele-specific…
…receiving these venetoclax-based combinations to identify molecular correlates of durable remission, response followed by relapse (adaptive resistance), or refractory disease (primary resistance). High response rates and durable remissions were typically…
…chronic health conditions. Dr. Gawad’s lab has been working on using single-cell DNA sequencing, which can provide a high-resolution view of the clonal diversity present in our hematopoietic cells as…
…and the clonality of the tumor. The two-step workflow and proprietary multiplex chemistry unlock access to DNA and more, allowing for high-throughput multi-omics analysis of single cells. Each droplet is…
Cancer is a complex disease, which is best understood at the single-cell analysis level to provide precise treatments and prevent relapse. Dennis Eastburn, PhD, discusses the next era in precision…
In this early proof-of-concept study, Dr. Koichi Takahashi from MD Anderson uses the newly available Tapestri Platform for high-throughput single-cell DNA sequencing of acute myeloid leukemia (AML) tumors. Sophisticated microfluidics…
…co-detect SNVs, indels, CNVs, and immunophenotypes from the same cell with a single, high-throughput workflow. Single-cell multi-modal sequencing unlocks the ability to truly understand clonal architecture and resolve tumor heterogeneity….
…Bio Tapestri Platform for single-cell analysis. See how researchers are using this groundbreaking technology to study single-cell multi-omics of DNA and Protein for the first time in a high-throughput fashion….
As a pioneer in high-throughput single-cell DNA multi-omics analysis, Mission Bio has developed a platform to genotype and phenotype from the same cell. Hear from Mission Bio Staff Scientist, Dr….
…a live audience from Asia how the Tapestri Platform works and showcases the novel capability to co-detect SNVs, CNVs, and immunophenotype from the same cell with a single high-throughput workflow….
…a live audience from Europe how the Tapestri Platform works and showcases the novel capability to co-detect SNVs, CNVs, and immunophenotype from the same cell with a single high-throughput workflow….
…Daniel chatted with us about their exciting findings regarding the genetics of cerebral cavernous malformations. Brittany Enzmann: Can you tell us about your research on cardiovascular disease and how you…
Understanding the mechanisms that allow clonal hematopoietic stem cells (HSCs) to expand and cause disease will be critical for developing strategies to identify patients at high risk for adverse clinical…
…agents, it is imperative that engineered cells be characterized with a high degree of accuracy and sensitivity. Measuring genomic manipulations at a single-cell level provides the most robust characterization of…
…peer-reviewed publications. Published Panel Highlights: Demonstrated performance on clinical samples via publications in high impact peer-reviewed journals Pre-designed, ready-to-use content accelerates oligo designing & ordering (content curated by investigators in…
…your research focus in general? Sushree: On a broad spectrum, my research focuses on knowing the germline and the somatic factors that drive bone marrow failure diseases in the pediatric…
…complex mechanisms of resistance to quizartinib Investigated mechanisms of resistance to quizartinib in patients with FLT3-ITD mutated AML. Wang, F. et al., Nature Communications Leukemia stemness and co-occurring mutations drive…
…individual cells, providing clonal insight in tandem with immunophenotype from rare residual disease cells. These high-resolution, integrated molecular profiles bring unprecedented clarity to the complex biology of AML MRD, powering…
…will discuss how singlecell DNA sequencing allowed high-sensitivity detection of driver mutations that bulk next generation sequencing didn’t call, identifying minute subclones at the time of CLL diagnosis which were…
…turnouts we’ve seen post COVID. It was quite the weekend, packed with oral and poster sessions from researchers and doctors unwavering in their commitment to advance clinical research, find new…
…targeted modifications in genetic sequences. However, the power of CRISPR comes with a complex challenge– edits often yield heterogeneous outcomes. In this session, Travis Hardcastle, Product Manager at Synthego, and…
…cohorts harboring human tumors that share an identical clonal barcode composition. The CRTs were derived from multiple patient-derived xenograft (PDX) models exhibiting high biological clonal diversity, as validated through single-cell…
Multiple myeloma (MM) is marked by multiple subclones exhibiting high mutational burden and chromosomal abnormalities. It arises from expanding pre-existing clonal populations such as monoclonal gammopathy of uncertain significance (MGUS)…
…Director of Scientific Affairs, presented to a packed crowd. Here we recap Gema’s presentation. Unraveling the Complexity of Cancer Evolution & Therapy Response Gema kicked things off by introducing the…
In this webinar, Rachel Agoglia, PhD, Sr. Field Application & Bioinformatics Scientist, Mission Bio, provides a comprehensive overview of how to get started with the Tapestri Platform, including the workflow…
Cancer is a complex disease with a mix of cells with varied states, and understanding of the disease state at the cellular level is required for better therapies. A single-cell…
…the clonal heterogeneity of cancers or the performance of gene-editing protocols across thousands of single cells. Our Tapestri Designer software allows you to complete custom designs quickly and easily. …
It is essential to develop new capabilities for assessing genetic variation present in rare cells and to better understand the role that these cells play in the evolution of tumor…
To improve variant calling and minimal residual disease (MRD) detection we developed a novel consensus sequence-based method for correcting the errors and reducing the false-positive rates….
AML has a poor prognosis, mainly due to relapse. Single-cell DNA sequencing technologies like the Mission Bio Tapestri Platform enable us to understand the clonal heterogeneity of AML patient samples…..
Recent advancements in genomic analysis of tumors have revealed that cancer disease evolves by a reiterative process of somatic variation, clonal expansion, and selection. Therefore, intra- and inter-tumor genomic heterogeneity…
Genomics data alone provides only partial insights into the cell’s type, state, or function. To obtain a more complete picture and reveal the cell’s phenotypic character, a multi-omics approach is…
Through single-cell sequencing technologies, it is now possible to interrogate thousands of cells in a single experiment for genetic variability. Single-cell DNA platforms like Tapestri are still susceptible to errors…
…were analyzed, and more than 700,000 cells were sequenced. They determined that the level of clonal complexity rises with disease progression. In particular, not all mutation combinations are equal, and…
We recently spoke with Dr. Cummins about her research, use of the Tapestri Platform, and thoughts on single-cell multi-omics and cell therapies for leukemias….
…it has impacted research in AML. Dr. Levine discusses the importance of clonal evolution in the fight against myeloid malignancies and how this is uncovered directly using single-cell sequencing. He…
…better understand which combinations of mutations are important for driving bladder cancer, Dr. John Lee from the Fred Hutch Institute combines sophisticated genome editing, organoid, and mouse model approaches with…
Minimal Residual Disease (MRD) detection and monitoring hold great promise to be used in clinical trials and beyond patient therapy selection. If single nucleotide variants (SNVs) are detected early on,…
Challenging the dogma that single nucleotide variants (SNVs) in RNA splicing factors do not occur in the same cell due to their synthetic lethal interactions and/or convergent effects, Dr. Justin…
Have you ever wondered what were the exact indels that were made to the DNA after genome editing experiments? Have you wondered what percentage of the cells had certain edits?…
Genomics data alone provides only partial insights into the cell’s type, state, or function. To obtain a more complete picture and reveal the cell’s phenotypic character, a multi-omics approach is…
Understanding the genomic landscape of cancer in single cells can be valuable for understanding tumor evolution and developing treatment regimens. This poster presents a muli-modal approach on the Tapestri Platform,…
This poster demonstrates the capability of the Tapestri Platform multi-omics workflow (which analyzes the DNA and protein information from the same cells) to discriminate cell populations. Using a two-donor PBMC…
The Tapestri Platform provides an unprecedented level of quantification of DNA integrations in significantly less time compared to other techniques such as qPCR and does so at single-cell resolution. These…
At Mission Bio, we applaud the research that has been accomplished over the years using our innovative single-cell multi-omics platform, Tapestri. We compiled a list of publications that utilize single-cell…
The inclusion of intracellular protein detection enables the measurement of pivotal proteins in cancer mechanisms, including apoptosis (BCL2 family proteins), transcription factors (GATA3), tumor suppressors (TP53), as well as phosphorylated…
There is a lack of data on CNV in single cells in solid tumor samples. We demonstrate single-cell DNA sequencing using the Tapestri instrument for solid tumor samples and an…
Cell and gene therapies are transformative solutions for diseases where existing interventions are ineffective. Many such therapies rely on the introduction of transgenes into host cells using viral or non-viral…
Cancer is a disease driven by genomic mutation and selection. While the advent of next generation sequencing has revolutionized genomic analysis, the data obtained from bulk sequencing do not represent…
CRISPR is a powerful tool for the development of novel cell and gene therapies. Despite its ability to precisely alter the genome, CRISPR can yield off-target edits and rare chromosomal…
…safety and efficacy. Yet, conventional methods for measuring gene transfer lack the resolution and representation to truly reflect sample composition and either report a population average (bulk) or involve laborious…
…for 1/3rd of all meningiomas. NF2-wild type meningiomas are commonly associated with mutations in SMO, POLR2A, PIK3CA, AKT1, and KLF4 mutations, the latter both occur regularly with TRAF7 mutations. The…
Accelerate your hematologic oncology projects with a dedicated partner across the drug development pipeline through the Pharma Assay Development Biomarker Discovery pilot program….
Servier worked with Mission Bio’s Pharma Assay Development (PAD) services to utilize the Tapestri® single-cell DNA sequencing technology to serially assess hundreds of samples from patients with IDH1-mutated AML who…
…their safety and efficacy. Yet, conventional methods for measuring gene transfer lack the resolution and representation to truly reflect sample composition and either report a population average (bulk) or involve…
…clonal outgrowth steps and hours of computational work. With the Tapestri single-cell platform you can rapidly capture genome editing outcomes and confidently validate your engineered cell therapy or CRISPR-based disease…
…safety and efficacy. Yet, conventional methods for measuring gene transfer lacks the resolution and representation to truly reflect sample composition and either report a population average (bulk) or involve laborious…
Cell and gene therapies are notoriously difficult to characterize. Yet, early and thorough characterization is key to advancing therapeutic programs quickly with minimal risk of safety issues or clinical holds….
Transformation from chronic (CP) to blast phase (BP) in myeloproliferative neoplasm (MPN) remains poorly characterized, and no specific mutation pattern has been highlighted. BP-MPN represents an unmet need, due to…
…heterozygous, compound heterozygous), and their functional impact all contribute to the layer of complexity in the mosaicism of editing outcomes. Current genome editing analyses primarily rely on bulk methods, which,…
…(homozygous, heterozygous, compound heterozygous), and their phenotypic effects all contribute to the layer of complexity to the mosaicism of editing’s outcomes. Current genome editing analyses primarily rely on bulk methods…
Sample multiplexing allows multiple samples to be pooled and processed simultaneously in a single run on the Tapestri Platform to achieve higher throughput and cost-efficiency while maintaining the same robust…
Sample multiplexing allows multiple samples to be pooled and processed simultaneously in a single run on the Tapestri Platform to achieve higher throughput and cost-efficiency while maintaining the same robust…
Tapestri single-cell multiomics analysis can transform how you tackle the complexities of multiple myeloma (MM) and its precursor stages by integrating genomic, proteomic, and clonotypic subclonal assessment with single-cell resolution,…
…(PDXs) represent a groundbreaking approach that has reshaped our capacity to investigate, comprehend, and address diseases. Leveraging the synergy of single-cell DNA sequencing and PDXs has empowered us to unveil…
…long-term surveillance. Being able to more comprehensively identify low-frequency subclones that may result in frank disease or resistance would enable more direct application of precision therapies. Here, we present proof…
…from the diagnostic population. These methods are commonly discordant, leading to clinical questions for individual surveillance and treatment. Combining these assays with single-cell resolution overcomes these limitations and reveals subclonal…
…long-term surveillance. Being able to more comprehensively identify low frequency subclones that may result in frank disease or resistance would enable more direct application of precision therapies. Here, we present…
